| Tissue Specificity | Expressed at high levels in testis. |
| Function | mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur. |
| Protein Name | Selenocysteine Insertion Sequence-Binding Protein 2Secis-Binding Protein 2 |
| Database Links | Reactome: R-HSA-2408557 |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: Mitochondrion |
| Alternative Antibody Names | Anti-Selenocysteine Insertion Sequence-Binding Protein 2 antibodyAnti-Secis-Binding Protein 2 antibodyAnti-SECISBP2 antibodyAnti-SBP2 antibody |
Information sourced from Uniprot.org
