Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Protein Transport Protein Sec61 Subunit Beta (1-96) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | SEC61B |
Gene ID: | 10952 |
Uniprot ID: | SC61B_HUMAN |
Immunogen Region: | 1-96 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-96 of human SEC61B (NP_006799.1). |
Immunogen Sequence: | MPGPTPSGTNVGSSGRSPSK AVAARAAGSTVRQRKNASCG TRSAGRTTSAGTGGMWRFYT EDSPGLKVGPVPVLVMSLLF IASVFMLHIWGKYTRS |
Function | Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. |
Protein Name | Protein Transport Protein Sec61 Subunit Beta |
Database Links | Reactome: R-HSA-1236974 Reactome: R-HSA-1799339 Reactome: R-HSA-9609523 |
Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Membrane Protein |
Alternative Antibody Names | Anti-Protein Transport Protein Sec61 Subunit Beta antibody Anti-SEC61B antibody |
Information sourced from Uniprot.org