Anti-SEC61A1 antibody (333-383 aa) (STJ194167)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human S61A1 at the amino acid range 333-383
General Information
| Short Description | Rabbit polyclonal anti-Protein transport protein Sec61 subunit alpha isoform 1 (333-383 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SEC61A1 |
| Gene ID | 29927 |
| Uniprot ID | S61A1_HUMAN |
| Immunogen | Synthesized peptide derived from the human S61A1 at the amino acid range 333-383 |
| Immunogen Region | 333-383 aa |
| Specificity | This antibody detects endogenous levels of S61A1 at Human/Mouse/Rat |
Additional Info
| Function | Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis. Plays a critical role in nephrogenesis, specifically at pronephros stage. |
| Protein Name | Protein Transport Protein Sec61 Subunit Alpha Isoform 1Sec61 Alpha-1 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-1799339 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLocalizes Exclusively In Granular Structures In The Endoplasmic Reticulum (Er) |
| Alternative Antibody Names | Anti-Protein Transport Protein Sec61 Subunit Alpha Isoform 1 antibodyAnti-Sec61 Alpha-1 antibodyAnti-SEC61A1 antibodyAnti-SEC61A antibody |
Information sourced from Uniprot.org