| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4196RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SEC24D |
| Gene ID: | 9871 |
| Uniprot ID: | SC24D_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SEC24D (NP_001304995.1). |
| Immunogen Sequence: | MSQQGYVATPPYSQPQPGIG LSPPHYGHYGDPSHTASPTG MMKPAGPLGATATRGMLPPG PPPPGPHQFGQNGAHATGHP PQRFPGPPPVNNVASSHAPY |
| Tissue Specificity | Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver. |
| Function | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor TMED10. May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5. |
| Protein Name | Protein Transport Protein Sec24dSec24-Related Protein D |
| Database Links | Reactome: R-HSA-1655829Reactome: R-HSA-204005Reactome: R-HSA-2132295Reactome: R-HSA-5694530Reactome: R-HSA-9705671Reactome: R-HSA-983170 |
| Cellular Localisation | Cytoplasmic VesicleCopii-Coated Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideEndoplasmic Reticulum MembraneCytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Transport Protein Sec24d antibodyAnti-Sec24-Related Protein D antibodyAnti-SEC24D antibodyAnti-KIAA0755 antibody |
Information sourced from Uniprot.org