| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SDHB |
| Gene ID: | 6390 |
| Uniprot ID: | SDHB_HUMAN |
| Immunogen Region: | 29-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-280 of human SDHB (NP_002991.2). |
| Immunogen Sequence: | AQTAAATAPRIKKFAIYRWD PDKAGDKPHMQTYEVDLNKC GPMVLDALIKIKNEVDSTLT FRRSCREGICGSCAMNINGG NTLACTRRIDTNLNKVSKIY PLPHMYVIKDLVPDLSNFYA QYKSIEPYLKKKDESQEGKQ QYLQSIEEREKLDGLYECIL CACCSTSCPSYWWNGDKYLG PAVLMQAYRWMIDSRDDFTE ERLAKLQDPFSLYRCHTIMN CTRTCPKGLNPGKAIAEIK |
| Function | Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. |
| Protein Name | Succinate Dehydrogenase Ubiquinone Iron-Sulfur Subunit - MitochondrialIron-Sulfur Subunit Of Complex IiIpMalate Dehydrogenase Quinone Iron-Sulfur Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-71403Reactome: R-HSA-9854311 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Antibody Names | Anti-Succinate Dehydrogenase Ubiquinone Iron-Sulfur Subunit - Mitochondrial antibodyAnti-Iron-Sulfur Subunit Of Complex Ii antibodyAnti-Ip antibodyAnti-Malate Dehydrogenase Quinone Iron-Sulfur Subunit antibodyAnti-SDHB antibodyAnti-SDH antibodyAnti-SDH1 antibody |
Information sourced from Uniprot.org