Host: | Rabbit |
Applications: | ELISA/WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-SDC1 (250-350) is suitable for use in ELISA and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
Purification: | Affinity Purified |
Concentration: | 0.55-0.61 µg/µl |
Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | SDC1 |
Gene ID: | 6382 |
Uniprot ID: | SDC1_HUMAN |
Immunogen Region: | 250-350 |
Immunogen: | C-epitope synthetic peptide taken within amino acid region 250-350 on human Syndecan-1 protein. |
Tissue Specificity | Detected in placenta (at protein level). Detected in fibroblasts (at protein level). |
Post Translational Modifications | Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. |
Function | Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway. |
Protein Name | Syndecan-1 Synd1 Cd Antigen Cd138 |
Database Links | Reactome: R-HSA-1971475 Reactome: R-HSA-2022928 Reactome: R-HSA-2024096 Reactome: R-HSA-202733 Reactome: R-HSA-3000170 Reactome: R-HSA-3560783 Reactome: R-HSA-3560801 Reactome: R-HSA-3656237 Reactome: R-HSA-3656253 Reactome: R-HSA-4420332 Reactome: R-HSA-449836 Reactome: R-HSA-9694614 Reactome: R-HSA-975634 Reactome: R-HSA-9820960 Reactome: R-HSA-9833110 |
Cellular Localisation | Membrane Single-Pass Type I Membrane Protein Secreted Extracellular Exosome Shedding Of The Ectodomain Produces A Soluble Form |
Alternative Antibody Names | Anti-Syndecan-1 antibody Anti-Synd1 antibody Anti-Cd Antigen Cd138 antibody Anti-SDC1 antibody Anti-SDC antibody |
Information sourced from Uniprot.org