Anti-SCUBE3 antibody (STJA0008000)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SCUBE3
Gene ID:	222663
Uniprot ID:	SCUB3_HUMAN
Specificity:	This antibody detects endogenous levels of SCUBE3 at Human, Mouse
Immunogen:	Synthesized peptide derived from human SCUBE3

Post Translational Modifications	N-glycosylated. Proteolytic cleavage produces a CUB-containing C-terminal fragment that retains the ability to bind to TGFBR2. This reaction is catalyzed in vitro by MMP2 and, to a lesser extent, by MMP9.
Function	Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors. It is required for ligand-induced recruitment of BMP receptors to lipid rafts. Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
Protein Name	Signal Peptide - Cub And Egf-Like Domain-Containing Protein 3
Database Links	Reactome: R-HSA-1474228
Cellular Localisation	Secreted Cell Surface
Alternative Antibody Names	Anti-Signal Peptide - Cub And Egf-Like Domain-Containing Protein 3 antibody Anti-SCUBE3 antibody Anti-CEGF3 antibody

Information sourced from Uniprot.org

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