• Western blot analysis of lysates from HuvEc cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-SCP2 antibody (STJ194498)

SKU:
STJ194498

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human, Mouse, Rat
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-Sterol Carrier Protein 2 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SCP2
Gene ID: 6342
Uniprot ID: SCP2_HUMAN
Specificity: SCP2 polyclonal antibody (Sterol Carrier Protein 2) binds to endogenous Sterol Carrier Protein 2.
Immunogen: Synthesized peptide derived from human NLTP
Post Translational Modifications Isoform SCP2: preSCP2, a protein with a molecular mass of about 15 kDa, is processed into its mature form (SCP2) by proteolytic cleavage of a 20 residue leader sequence after translocation into peroxisomes.
Function Isoform SCPx: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs. Isoform SCP2: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
Protein Name Sterol Carrier Protein 2
Scp-2
Acetyl-Coa C-Myristoyltransferase
Non-Specific Lipid-Transfer Protein
Nsl-Tp
Propanoyl-Coa C-Acyltransferase
Scp-2/3-Oxoacyl-Coa Thiolase
Scp-2/Thiolase
Scp-Chi
Scpx
Sterol Carrier Protein X
Scp-X
Straight-Chain Acyl-Coa Oxidase
Scox
Database Links Reactome: R-HSA-193368 P22307-1
Reactome: R-HSA-2046106
Reactome: R-HSA-389887 P22307-1
Reactome: R-HSA-9033241
Reactome: R-HSA-9033500
Cellular Localisation Isoform Scp2: Peroxisome
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Isoform Scpx: Peroxisome
Alternative Antibody Names Anti-Sterol Carrier Protein 2 antibody
Anti-Scp-2 antibody
Anti-Acetyl-Coa C-Myristoyltransferase antibody
Anti-Non-Specific Lipid-Transfer Protein antibody
Anti-Nsl-Tp antibody
Anti-Propanoyl-Coa C-Acyltransferase antibody
Anti-Scp-2/3-Oxoacyl-Coa Thiolase antibody
Anti-Scp-2/Thiolase antibody
Anti-Scp-Chi antibody
Anti-Scpx antibody
Anti-Sterol Carrier Protein X antibody
Anti-Scp-X antibody
Anti-Straight-Chain Acyl-Coa Oxidase antibody
Anti-Scox antibody
Anti-SCP2 antibody

Information sourced from Uniprot.org

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