Anti-SCN9A antibody (651-700) (STJ94332)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human SCN9A. AA range:651-700
General Information
| Short Description | Rabbit polyclonal anti-Sodium channel protein type 9 subunit alpha (651-700) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCN9A |
| Gene ID | 6335 |
| Uniprot ID | SCN9A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SCN9A. AA range:651-700 |
| Immunogen Region | 651-700 |
| Specificity | Na+ CP type IX Alpha Polyclonal Antibody detects endogenous levels of Na+ CP type IX Alpha protein. |
Additional Info
| Tissue Specificity | Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Also expressed in vagus nerves within the head and neck region. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion. |
| Post Translational Modifications | Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. Ubiquitinated by NEDD4L.which may promote its endocytosis. |
| Function | Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain. |
| Protein Name | Sodium Channel Protein Type 9 Subunit AlphaNeuroendocrine Sodium ChannelHne-NaPeripheral Sodium Channel 1Pn1Sodium Channel Protein Type Ix Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.7 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionNeuron ProjectionAxonLocalizes To Neuron TerminalsAlso Detected At Nodes Of Ranvier |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 9 Subunit Alpha antibodyAnti-Neuroendocrine Sodium Channel antibodyAnti-Hne-Na antibodyAnti-Peripheral Sodium Channel 1 antibodyAnti-Pn1 antibodyAnti-Sodium Channel Protein Type Ix Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.7 antibodyAnti-SCN9A antibodyAnti-NENA antibody |
Information sourced from Uniprot.org