| Tissue Specificity | Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Also expressed in vagus nerves within the head and neck region. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion. |
| Post Translational Modifications | Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. Ubiquitinated by NEDD4L.which may promote its endocytosis. |
| Function | Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain. |
| Protein Name | Sodium Channel Protein Type 9 Subunit AlphaNeuroendocrine Sodium ChannelHne-NaPeripheral Sodium Channel 1Pn1Sodium Channel Protein Type Ix Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.7 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionNeuron ProjectionAxonLocalizes To Neuron TerminalsAlso Detected At Nodes Of Ranvier |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 9 Subunit Alpha antibodyAnti-Neuroendocrine Sodium Channel antibodyAnti-Hne-Na antibodyAnti-Peripheral Sodium Channel 1 antibodyAnti-Pn1 antibodyAnti-Sodium Channel Protein Type Ix Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.7 antibodyAnti-SCN9A antibodyAnti-NENA antibody |
Information sourced from Uniprot.org
