• Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SCN9A Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Na+ CP type IX Alpha Polyclonal Antibody diluted at 1：1000

Anti-SCN9A antibody (651-700) (STJ94332)

SKU:
STJ94332

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Sodium channel protein type 9 subunit alpha (651-700) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SCN9A
Gene ID: 6335
Uniprot ID: SCN9A_HUMAN
Immunogen Region: 651-700
Specificity: Na+ CP type IX Alpha Polyclonal Antibody detects endogenous levels of Na+ CP type IX Alpha protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human SCN9A. AA range:651-700
Tissue Specificity Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Also expressed in vagus nerves within the head and neck region. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion.
Post Translational Modifications Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. Ubiquitinated by NEDD4L.which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.
Function Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Protein Name Sodium Channel Protein Type 9 Subunit Alpha
Neuroendocrine Sodium Channel
Hne-Na
Peripheral Sodium Channel 1
Pn1
Sodium Channel Protein Type Ix Subunit Alpha
Voltage-Gated Sodium Channel Subunit Alpha Nav1.7
Database Links Reactome: R-HSA-445095
Reactome: R-HSA-5576892
Reactome: R-HSA-9717207
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Neuron Projection
In Neurite Terminals
Alternative Antibody Names Anti-Sodium Channel Protein Type 9 Subunit Alpha antibody
Anti-Neuroendocrine Sodium Channel antibody
Anti-Hne-Na antibody
Anti-Peripheral Sodium Channel 1 antibody
Anti-Pn1 antibody
Anti-Sodium Channel Protein Type Ix Subunit Alpha antibody
Anti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.7 antibody
Anti-SCN9A antibody
Anti-NENA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance