| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Monkey |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sodium channel protein type 7 subunit alpha (771-820) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-p 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCN7A |
| Gene ID: |
6332 |
| Uniprot ID: |
SCN7A_HUMAN |
| Immunogen Region: |
771-820 |
| Specificity: |
Na+ CP type VII Alpha Polyclonal Antibody detects endogenous levels of Na+ CP type VII Alpha protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human SCN7A. AA range:771-820 |
| Tissue Specificity | Heart and uterus. |
| Function | Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body. By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis. |
| Protein Name | Sodium Channel Protein Type 7 Subunit AlphaAtypical Sodium Channel Nav2.1Nax ChannelSodium Channel Protein Type Vii Subunit Alpha |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 7 Subunit Alpha antibodyAnti-Atypical Sodium Channel Nav2.1 antibodyAnti-Nax Channel antibodyAnti-Sodium Channel Protein Type Vii Subunit Alpha antibodyAnti-SCN7A antibodyAnti-SCN6A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
