| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCN7A (265-368) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCN7A |
| Gene ID: |
6332 |
| Uniprot ID: |
SCN7A_HUMAN |
| Immunogen Region: |
265-368 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 265-368 of human SCN7A (NP_002967.2). |
| Immunogen Sequence: |
HKCFRWPQENENETLHNRTG NPYYIRETENFYYLEGERYA LLCGNRTDAGQCPEGYVCVK AGINPDQGFTNFDSFGWALF ALFRLMAQDYPEVLYHQILY ASGK |
| Tissue Specificity | Heart and uterus. |
| Post Translational Modifications | Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 656) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. |
| Function | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. |
| Protein Name | Sodium Channel Protein Type 7 Subunit AlphaPutative Voltage-Gated Sodium Channel Subunit Alpha NaxSodium Channel Protein Cardiac And Skeletal Muscle Subunit AlphaSodium Channel Protein Type Vii Subunit Alpha |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 7 Subunit Alpha antibodyAnti-Putative Voltage-Gated Sodium Channel Subunit Alpha Nax antibodyAnti-Sodium Channel Protein Cardiac And Skeletal Muscle Subunit Alpha antibodyAnti-Sodium Channel Protein Type Vii Subunit Alpha antibodyAnti-SCN7A antibodyAnti-SCN6A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
