| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCN5A (1950-2016) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCN5A |
| Gene ID: |
6331 |
| Uniprot ID: |
SCN5A_HUMAN |
| Immunogen Region: |
1950-2016 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1950-2016 of human SCN5A (NP_932173.1). |
| Immunogen Sequence: |
YVMSENFSRPLGPPSSSSIS STSFPPSYDSVTRATSDNLQ VRGSDYSHSEDLADFPPSPD RDRESIV |
| Tissue Specificity | Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain. |
| Post Translational Modifications | Ubiquitinated by NEDD4L.which promotes its endocytosis. Does not seem to be ubiquitinated by NEDD4 or WWP2. Phosphorylation at Ser-1503 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents (Probable). Regulated through phosphorylation by CaMK2D. Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 868) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. |
| Function | This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. |
| Protein Name | Sodium Channel Protein Type 5 Subunit AlphaSodium Channel Protein Cardiac Muscle Subunit AlphaSodium Channel Protein Type V Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.5Hh1 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmPerinuclear RegionSarcolemmaT-TubuleCell JunctionRangrf Promotes Trafficking To The Cell MembraneColocalizes With Pkp2 At Intercalated Disks In The Heart |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 5 Subunit Alpha antibodyAnti-Sodium Channel Protein Cardiac Muscle Subunit Alpha antibodyAnti-Sodium Channel Protein Type V Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.5 antibodyAnti-Hh1 antibodyAnti-SCN5A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
