Anti-SCN5A antibody (1021-1034) (STJ72545)

SKU:
STJ72545-100

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Host: Goat
Applications: Pep-ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-SCN5A (1021-1034) is suitable for use in ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:16000.
WB: Preliminary experiments gave an approx 80kDa band in HeLa lysates after 0.3µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the b
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SCN5A
Gene ID: 6331
Uniprot ID: SCN5A_HUMAN
Immunogen Region: 1021-1034
Accession Number: NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1
Specificity: This antibody is expected to recognize all reported isoforms (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1).
Immunogen Sequence: PTRKETRFEEGEQP
Post Translational Modifications Ubiquitinated by NEDD4L.which promotes its endocytosis. Does not seem to be ubiquitinated by NEDD4 or WWP2. Phosphorylation at Ser-1503 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents (Probable). Regulated through phosphorylation by CaMK2D. Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 868) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. N-glycosylated at Asn-318, probably hinders potential interaction with regulatory subunits.
Function Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat. Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2.
Protein Name Sodium Channel Protein Type 5 Subunit Alpha
Sodium Channel Protein Cardiac Muscle Subunit Alpha
Sodium Channel Protein Type V Subunit Alpha
Voltage-Gated Sodium Channel Subunit Alpha Nav1.5
Hh1
Database Links Reactome: R-HSA-445095
Reactome: R-HSA-5576892
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cytoplasm
Perinuclear Region
Sarcolemma
T-Tubule
Cell Junction
Rangrf Promotes Trafficking To The Cell Membrane
Colocalizes With Pkp2 At Intercalated Disks In The Heart
Alternative Antibody Names Anti-Sodium Channel Protein Type 5 Subunit Alpha antibody
Anti-Sodium Channel Protein Cardiac Muscle Subunit Alpha antibody
Anti-Sodium Channel Protein Type V Subunit Alpha antibody
Anti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.5 antibody
Anti-Hh1 antibody
Anti-SCN5A antibody

Information sourced from Uniprot.org

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