Anti-SCN4A antibody (431-480) (STJ94331)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human SCN4A. AA range:431-480
General Information
| Short Description | Rabbit polyclonal anti-Sodium channel protein type 4 subunit alpha (431-480) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCN4A |
| Gene ID | 6329 |
| Uniprot ID | SCN4A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SCN4A. AA range:431-480 |
| Immunogen Region | 431-480 |
| Specificity | Na+ CP type IV Alpha Polyclonal Antibody detects endogenous levels of Na+ CP type IV Alpha protein. |
Additional Info
| Function | Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction. |
| Protein Name | Sodium Channel Protein Type 4 Subunit AlphaSkm1Sodium Channel Protein Skeletal Muscle Subunit AlphaSodium Channel Protein Type Iv Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.4 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 4 Subunit Alpha antibodyAnti-Skm1 antibodyAnti-Sodium Channel Protein Skeletal Muscle Subunit Alpha antibodyAnti-Sodium Channel Protein Type Iv Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.4 antibodyAnti-SCN4A antibody |
Information sourced from Uniprot.org