| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SCN3B |
| Gene ID: |
55800 |
| Uniprot ID: |
SCN3B_HUMAN |
| Immunogen Region: |
25-145 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-145 of human SCN3B (NP_001035241.1). |
| Immunogen Sequence: |
VCVEVPSETEAVQGNPMKLR CISCMKREEVEATTVVEWFY RPEGGKDFLIYEYRNGHQEV ESPFQGRLQWNGSKDLQDVS ITVLNVTLNDSGLYTCNVSR EFEFEAHRPFVKTTRLIPLR V |
| Tissue Specificity | Expressed in the atrium. |
| Post Translational Modifications | Intramolecular disulfide bonds favor the voltage-gated sodium channel oligomeric complex assembly. N-glycosylated. |
| Function | Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation of the channel and increasing the fraction of channels operating in the fast gating mode. Modulates the activity of SCN5A/Nav1.5. Could also regulate the atypical sodium channel SCN7A/Nav2.1. Modulates the activity of SCN10A/Nav1.8, regulating its oligomerization and accelerating the recovery from inactivation. |
| Protein Name | Sodium Channel Regulatory Subunit Beta-3 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Regulatory Subunit Beta-3 antibodyAnti-SCN3B antibodyAnti-KIAA1158 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
