| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCN2A (275-401) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCN2A |
| Gene ID: |
6326 |
| Uniprot ID: |
SCN2A_HUMAN |
| Immunogen Region: |
275-401 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 275-401 of human SCN2A (NP_001035232.1). |
| Immunogen Sequence: |
RNKCLQWPPDNSSFEINITS FFNNSLDGNGTTFNRTVSIF NWDEYIEDKSHFYFLEGQND ALLCGNSSDAGQCPEGYICV KAGRNPNYGYTSFDTFSWAF LSLFRLMTQDFWENLYQLTL RAAGKTY |
| Post Translational Modifications | May be ubiquitinated by NEDD4L.which would promote its endocytosis. Phosphorylation at Ser-1506 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. Sumoylated at Lys-38. Sumoylation is induced by hypoxia, increases voltage-gated sodium current and mediates the early response to acute hypoxia in neurons. Sumoylated SCN2A is located at the cell membrane. |
| Function | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory. |
| Protein Name | Sodium Channel Protein Type 2 Subunit AlphaHbsc IiSodium Channel Protein Brain Ii Subunit AlphaSodium Channel Protein Type Ii Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.2 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 2 Subunit Alpha antibodyAnti-Hbsc Ii antibodyAnti-Sodium Channel Protein Brain Ii Subunit Alpha antibodyAnti-Sodium Channel Protein Type Ii Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.2 antibodyAnti-SCN2A antibodyAnti-NAC2 antibodyAnti-SCN2A1 antibodyAnti-SCN2A2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
