| Post Translational Modifications | May be ubiquitinated by NEDD4L.which would promote its endocytosis. Phosphorylation at Ser-1506 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. Sumoylated at Lys-38. Sumoylation is induced by hypoxia, increases voltage-gated sodium current and mediates the early response to acute hypoxia in neurons. Sumoylated SCN2A is located at the cell membrane. |
| Function | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory. |
| Protein Name | Sodium Channel Protein Type 2 Subunit AlphaHbsc IiSodium Channel Protein Brain Ii Subunit AlphaSodium Channel Protein Type Ii Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.2 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 2 Subunit Alpha antibodyAnti-Hbsc Ii antibodyAnti-Sodium Channel Protein Brain Ii Subunit Alpha antibodyAnti-Sodium Channel Protein Type Ii Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.2 antibodyAnti-SCN2A antibodyAnti-HBA antibodyAnti-NAC2 antibodyAnti-SCN2A1 antibodyAnti-SCN2A2 antibody |
Information sourced from Uniprot.org
