Anti-SCN1A antibody (STJ193174)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SCN1A
General Information
| Short Description | Rabbit polyclonal anti-Sodium channel protein type 1 subunit alpha for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCN1A |
| Gene ID | 6323 |
| Uniprot ID | SCN1A_HUMAN |
| Immunogen | Synthesized peptide derived from the human SCN1A |
| Specificity | This antibody detects endogenous levels of human SCN1A |
Additional Info
| Function | Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits. Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain. |
| Protein Name | Sodium Channel Protein Type 1 Subunit AlphaSodium Channel Protein Brain I Subunit AlphaSodium Channel Protein Type I Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.1 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 1 Subunit Alpha antibodyAnti-Sodium Channel Protein Brain I Subunit Alpha antibodyAnti-Sodium Channel Protein Type I Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.1 antibodyAnti-SCN1A antibodyAnti-NAC1 antibodyAnti-SCN1 antibody |
Information sourced from Uniprot.org