| Function | Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarization. |
| Protein Name | Sodium Channel Protein Type 11 Subunit AlphaPeripheral Nerve Sodium Channel 5Pn5Sensory Neuron Sodium Channel 2Sodium Channel Protein Type Xi Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.9Hnan |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 11 Subunit Alpha antibodyAnti-Peripheral Nerve Sodium Channel 5 antibodyAnti-Pn5 antibodyAnti-Sensory Neuron Sodium Channel 2 antibodyAnti-Sodium Channel Protein Type Xi Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.9 antibodyAnti-Hnan antibodyAnti-SCN11A antibodyAnti-SCN12A antibodyAnti-SNS2 antibody |
Information sourced from Uniprot.org
