| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCN11A (Internal Region) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Scn11a |
| Gene ID: |
24046 |
| Uniprot ID: |
SCNBA_MOUSE |
| Immunogen Region: |
Internal Region |
| Specificity: |
Specific for SCN11A. |
| Immunogen: |
A synthetic peptide from the internal region of mouse SCN11A conjugated to blue carrier protein was used as the antigen. |
| Function | Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarization. |
| Protein Name | Sodium Channel Protein Type 11 Subunit AlphaNanSensory Neuron Sodium Channel 2Sodium Channel Protein Type Xi Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.9 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 11 Subunit Alpha antibodyAnti-Nan antibodyAnti-Sensory Neuron Sodium Channel 2 antibodyAnti-Sodium Channel Protein Type Xi Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.9 antibodyAnti-Scn11a antibodyAnti-Nan antibodyAnti-Nat antibodyAnti-Sns2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
