| Short Description : | Rabbit polyclonal SCIN (1-100) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SCIN |
| Gene ID: | 85477 |
| Uniprot ID: | SCIN_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen Sequence: | MARELYHEEFARAGKQAGLQ VWRIEKLELVPVPQSAHGDF YVGDAYLVLHTAKTSRGFTY HLHFWLGKECSQDESTAAAI FTVQMDDYLGGKPVQNRELQ |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SCIN (NP_001106177.1). |
| Tissue Specificity | Expressed in megakaryocytes. |
| Function | Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways. |
| Protein Name | ScinderinAdseverin |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionPodosome |
| Alternative Antibody Names | Anti-Scinderin antibodyAnti-Adseverin antibodyAnti-SCIN antibodyAnti-KIAA1905 antibody |
Information sourced from Uniprot.org
