Anti-SCG3 antibody (199-468) (STJ110109)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SCG3 (199-468) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCG3 |
| Gene ID | 29106 |
| Uniprot ID | SCG3_HUMAN |
| Immunogen Region | 199-468 |
| Immunogen Sequence | KLISKEANNYEEDPNKPTSW TENQAGKIPEKVTPMAAIQD GLAKGENDETVSNTLTLTNG LERRTKTYSEDNFEELQYFP NFYALLKSIDSEKEAKEKET LITIMKTLIDFVKMMVKYGT ISPEEGVSYLENLDEMIALQ TKNKLEKNATDNISKLFPAP SEKSHEETDSTKEEAAKMEK EYGSLKDSTKDDNSNPGGKT DEPKGKTEAYLEAIRKNIEW LKKHDKKGNKEDYDLSKMR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 199-468 of human SCG3 (NP_037375.2). |
Additional Info
| Tissue Specificity | Detected in urine (at protein level). Expressed in brain, heart, kidney, liver and skeletal muscle. |
| Post Translational Modifications | O-glycosylated. |
| Function | Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. |
| Protein Name | Secretogranin-3Secretogranin IiiSgiii |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSecretory Vesicle MembranePeripheral Membrane ProteinSecretedAssociated With The Secretory Granule Membrane Through Direct Binding To Cholesterol-Enriched Lipid Rafts |
| Alternative Antibody Names | Anti-Secretogranin-3 antibodyAnti-Secretogranin Iii antibodyAnti-Sgiii antibodyAnti-SCG3 antibodyAnti-UNQ2502 antibodyAnti-PRO5990 antibody |
Information sourced from Uniprot.org