| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SCD |
| Gene ID: | 6319 |
| Uniprot ID: | SCD_HUMAN |
| Immunogen Region: | 25-43 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SCD (NP_005054.3). |
| Immunogen Sequence: | MPAHLLQDDISSSYTTTTTI TAPPSRVLQNGGDKLETMPL YLEDDIRPDIKDDIYDPTYK DKEGPSPKVEYVWRNIILMS LLHLGALYGITLIPTCKFYT |
| Tissue Specificity | Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung. |
| Function | Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation. Plays an important role in body energy homeostasis. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides. |
| Protein Name | Stearoyl-Coa Desaturase Hscd1 Acyl-Coa Desaturase Delta(9-Desaturase Delta-9 Desaturase Fatty Acid Desaturase |
| Database Links | Reactome: R-HSA-2426168 Reactome: R-HSA-75105 Reactome: R-HSA-9029558 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Stearoyl-Coa Desaturase antibody Anti-Hscd1 antibody Anti-Acyl-Coa Desaturase antibody Anti-Delta(9-Desaturase antibody Anti-Delta-9 Desaturase antibody Anti-Fatty Acid Desaturase antibody Anti-SCD antibody Anti-FADS5 antibody Anti-SCD1 antibody Anti-SCDOS antibody |
Information sourced from Uniprot.org