| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SCARB1/SR-BI (238-250) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000. WB: Approx 85kDa band observed in Human Adrenal gland lysates (calculated MW of 57.0kDa according to NP_005496.4). Recommended concentration: 0.01-0.03µg/ml. IHC: Paraffin embedded Hu |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SCARB1 |
| Gene ID: | 949 |
| Uniprot ID: | SCRB1_HUMAN |
| Immunogen Region: | 238-250 |
| Accession Number: | NP_005496.4; NP_001076428.1 |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_005496.4; NP_001076428.1). |
| Immunogen Sequence: | NGLSKVDFWHSDQ |
| Post Translational Modifications | N-glycosylated. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. |
| Function | Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate. (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus. (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding. |
| Protein Name | Scavenger Receptor Class B Member 1 Srb1 Cd36 And Limpii Analogous 1 Cla-1 Cd36 Antigen-Like 1 Collagen Type I Receptor - Thrombospondin Receptor-Like 1 Sr-Bi Cd Antigen Cd36 |
| Database Links | Reactome: R-HSA-3000471 Q8WTV0-2 Reactome: R-HSA-8964011 Q8WTV0-2 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Membrane Caveola Predominantly Localized To Cholesterol And Sphingomyelin-Enriched Domains Within The Plasma Membrane Called Caveolae |
| Alternative Antibody Names | Anti-Scavenger Receptor Class B Member 1 antibody Anti-Srb1 antibody Anti-Cd36 And Limpii Analogous 1 antibody Anti-Cla-1 antibody Anti-Cd36 Antigen-Like 1 antibody Anti-Collagen Type I Receptor - Thrombospondin Receptor-Like 1 antibody Anti-Sr-Bi antibody Anti-Cd Antigen Cd36 antibody Anti-SCARB1 antibody Anti-CD36L1 antibody Anti-CLA1 antibody |
Information sourced from Uniprot.org