| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-SCARB1/SR-BI (238-250) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.01-0.03µg/mlIHC-5µg/mlELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
SCARB1 |
| Gene ID: |
949 |
| Uniprot ID: |
SCRB1_HUMAN |
| Immunogen Region: |
238-250 |
| Accession Number: |
NP_005496.4; NP_001076428.1 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_005496.4; NP_001076428.1). |
| Immunogen Sequence: |
NGLSKVDFWHSDQ |
| Post Translational Modifications | N-glycosylated. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. |
| Function | Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate. (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus. (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding. |
| Protein Name | Scavenger Receptor Class B Member 1Srb1Cd36 And Limpii Analogous 1Cla-1Cd36 Antigen-Like 1Collagen Type I Receptor - Thrombospondin Receptor-Like 1Sr-BiCd Antigen Cd36 |
| Database Links | Reactome: R-HSA-3000471 Q8WTV0-2Reactome: R-HSA-8964011 Q8WTV0-2 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembraneCaveolaPredominantly Localized To Cholesterol And Sphingomyelin-Enriched Domains Within The Plasma MembraneCalled Caveolae |
| Alternative Antibody Names | Anti-Scavenger Receptor Class B Member 1 antibodyAnti-Srb1 antibodyAnti-Cd36 And Limpii Analogous 1 antibodyAnti-Cla-1 antibodyAnti-Cd36 Antigen-Like 1 antibodyAnti-Collagen Type I Receptor - Thrombospondin Receptor-Like 1 antibodyAnti-Sr-Bi antibodyAnti-Cd Antigen Cd36 antibodyAnti-SCARB1 antibodyAnti-CD36L1 antibodyAnti-CLA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
