| Short Description : | Rabbit polyclonal anti-SCAI (N-Term) for use in ELISA and WB in Chicken, Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | ELISA/WB |
| Host: | Rabbit |
| Reactivity: | Chicken/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:1000 |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction: | Storage at-20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20°C. |
| Gene Symbol: | Scai |
| Gene ID: | 320271 |
| Uniprot ID: | SCAI_MOUSE |
| Immunogen: | SCAI synthetic peptide (coupled to KLH) corresponding to amino acid residues in the N-terminal region of mouse SCAI. This peptide sequence is highly conserved in human, rat, mouse, and chicken SCAI. |
| Immunogen Region: | N-Term |
| Immunogen Sequence: | Mouse |
| Specificity: | The antibody detects a significant 66 kDa* protein corresponding to the molecular mass of SCAI on SDS-PAGE immunoblots of mouse brain and human A431 cells. In brain, the antibody also detects 53 and 41 kDa bands. |
| Tissue Specificity | Expressed in most tissues tested with higher expression levels in brain, spleen and thymus. |
| Function | Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. |
| Protein Name | Protein ScaiSuppressor Of Cancer Cell Invasion Protein |
| Database Links | Reactome: R-MMU-5663220 |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinNucleusCytoplasmNuclear Localization Is Required For Inhibition Of Mrtfa |
| Alternative Antibody Names | Anti-Protein Scai antibodyAnti-Suppressor Of Cancer Cell Invasion Protein antibodyAnti-Scai antibody |
Information sourced from Uniprot.org
