| Function | Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Acts as a suppressor of autophagy in neurons. Together with its binding partner, the phosphatase MTMR2, plays a role in dephosphorylation of phosphoinositides critical for autophagy initiation and autophagosome maturation. Plays a role in positively regulating late-stage radial sorting of large caliber axons, a process leading to myelination by Schwann cells, possibly via regulating endosomal trafficking. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. |
| Protein Name | Myotubularin-Related Protein 5Inactive Phosphatidylinositol 3-Phosphatase 5Set-Binding Factor 1Sbf1 |
| Database Links | Reactome: R-HSA-1483248Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell ProjectionNeuron ProjectionLocalized In Neuronal Somata And Processes With Punctate/Vesicular Morphology |
| Alternative Antibody Names | Anti-Myotubularin-Related Protein 5 antibodyAnti-Inactive Phosphatidylinositol 3-Phosphatase 5 antibodyAnti-Set-Binding Factor 1 antibodyAnti-Sbf1 antibodyAnti-SBF1 antibodyAnti-MTMR5 antibody |
Information sourced from Uniprot.org
