| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Myotubularin-related protein 5 (320-370 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SBF1 |
| Gene ID: |
6305 |
| Uniprot ID: |
MTMR5_HUMAN |
| Immunogen Region: |
320-370 aa |
| Specificity: |
This antibody detects endogenous levels of MTMR5 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human MTMR5 at the amino acid range 320-370 |
| Function | Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Acts as a suppressor of autophagy in neurons. Together with its binding partner, the phosphatase MTMR2, plays a role in dephosphorylation of phosphoinositides critical for autophagy initiation and autophagosome maturation. Plays a role in positively regulating late-stage radial sorting of large caliber axons, a process leading to myelination by Schwann cells, possibly via regulating endosomal trafficking. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. |
| Protein Name | Myotubularin-Related Protein 5Inactive Phosphatidylinositol 3-Phosphatase 5Set-Binding Factor 1Sbf1 |
| Database Links | Reactome: R-HSA-1483248Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell ProjectionNeuron ProjectionLocalized In Neuronal Somata And Processes With Punctate/Vesicular Morphology |
| Alternative Antibody Names | Anti-Myotubularin-Related Protein 5 antibodyAnti-Inactive Phosphatidylinositol 3-Phosphatase 5 antibodyAnti-Set-Binding Factor 1 antibodyAnti-Sbf1 antibodyAnti-SBF1 antibodyAnti-MTMR5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
