| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SATB2 (634-733) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SATB2 |
| Gene ID: |
23314 |
| Uniprot ID: |
SATB2_HUMAN |
| Immunogen Region: |
634-733 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 634-733 of human SATB2 (NP_001165980.1). |
| Immunogen Sequence: |
HDVGLYPDQEAIHTLSAQLD LPKHTIIKFFQNQRYHVKHH GKLKEHLGSAVDVAEYKDEE LLTESEENDSEEGSEEMYKV EAEEENADKSKAAPAEIDQR |
| Tissue Specificity | High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus. |
| Post Translational Modifications | Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity. |
| Function | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. |
| Protein Name | Dna-Binding Protein Satb2Special At-Rich Sequence-Binding Protein 2 |
| Database Links | Reactome: R-HSA-4551638Reactome: R-HSA-8940973 |
| Cellular Localisation | Nucleus Matrix |
| Alternative Antibody Names | Anti-Dna-Binding Protein Satb2 antibodyAnti-Special At-Rich Sequence-Binding Protein 2 antibodyAnti-SATB2 antibodyAnti-KIAA1034 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
