| Short Description : | Rabbit polyclonal anti-SAM and SH3 domain-containing protein 1 (373-423 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SASH1 |
| Gene ID: | 23328 |
| Uniprot ID: | SASH1_HUMAN |
| Immunogen: | Synthesized peptide derived from the human SASH1 at the amino acid range 373-423 |
| Immunogen Region: | 373-423 aa |
| Specificity: | This antibody detects endogenous levels of SASH1 at Human/Mouse |
| Function | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis. |
| Protein Name | Sam And Sh3 Domain-Containing Protein 1Proline-Glutamate Repeat-Containing Protein |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sam And Sh3 Domain-Containing Protein 1 antibodyAnti-Proline-Glutamate Repeat-Containing Protein antibodyAnti-SASH1 antibodyAnti-KIAA0790 antibodyAnti-PEPE1 antibody |
Information sourced from Uniprot.org
