| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SART3 (664-963) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SART3 |
| Gene ID: |
9733 |
| Uniprot ID: |
SART3_HUMAN |
| Immunogen Region: |
664-963 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 664-963 of human SART3 (NP_055521.1). |
| Immunogen Sequence: |
AGPAGKCAAVDVEPPSKQKE KAASLKRDMPKVLHDSSKDS ITVFVSNLPYSMQEPDTKLR PLFEACGEVVQIRPIFSNRG DFRGYCYVEFKEEKSALQAL EMDRKSVEGRPMFVSPCVDK SKNPDFKVFRYSTSLEKHKL FISGLPFSCTKEELEEICKA HGTVKDLRLVTNRAGKPKGL AYVEYENESQASQAVMKMDG MTIKENIIKVAISNPPQRKV PEKPETRKAPGGPMLLPQT |
| Tissue Specificity | Ubiquitously expressed. |
| Function | U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair. May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC. Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. |
| Protein Name | Squamous Cell Carcinoma Antigen Recognized By T-Cells 3Sart-3Tat-Interacting Protein Of 110 KdaTip110P110 Nuclear Rna-Binding Protein |
| Cellular Localisation | NucleusNucleoplasmCajal BodyNucleus SpeckleCytoplasm |
| Alternative Antibody Names | Anti-Squamous Cell Carcinoma Antigen Recognized By T-Cells 3 antibodyAnti-Sart-3 antibodyAnti-Tat-Interacting Protein Of 110 Kda antibodyAnti-Tip110 antibodyAnti-P110 Nuclear Rna-Binding Protein antibodyAnti-SART3 antibodyAnti-KIAA0156 antibodyAnti-TIP110 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
