| Host: |
Rabbit |
| Applications: |
WB/IP |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SARM1 (625-724) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IP 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SARM1 |
| Gene ID: |
23098 |
| Uniprot ID: |
SARM1_HUMAN |
| Immunogen Region: |
625-724 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 625-724 of human SARM1 (NP_055892.2). |
| Immunogen Sequence: |
ALDKCMQDHDCKDWVHKEIV TALSCGKNIVPIIDGFEWPE PQVLPEDMQAVLTFNGIKWS HEYQEATIEKIIRFLQGRSS RDSSAGSDTSLEGAAPMGPT |
| Tissue Specificity | Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta. |
| Post Translational Modifications | Phosphorylation at Ser-548 by JNK kinases (MAPK8, MAPK9 and /or MAPK10) enhance the NAD(+) hydrolase (NADase) activity. Phosphorylation at Ser-548 and subsequent activation takes place in response to oxidative stress conditions and inhibits mitochondrial respiration. |
| Function | NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide.NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. |
| Protein Name | Nad(+ Hydrolase Sarm1Nadase Sarm1Hsarm1Nadp(+ Hydrolase Sarm1Sterile Alpha And Armadillo Repeat ProteinSterile Alpha And Tir Motif-Containing Protein 1Sterile Alpha Motif Domain-Containing Protein 2Myd88-5Sam Domain-Containing Protein 2Tir-1 HomologHstir |
| Database Links | Reactome: R-HSA-166166 Q6SZW1-1Reactome: R-HSA-168164 Q6SZW1-1Reactome: R-HSA-936964 Q6SZW1-1Reactome: R-HSA-937041 Q6SZW1-1Reactome: R-HSA-937072 Q6SZW1-1 |
| Cellular Localisation | CytoplasmCell ProjectionAxonDendriteSynapseMitochondrionAssociated With Microtubules |
| Alternative Antibody Names | Anti-Nad(+ Hydrolase Sarm1 antibodyAnti-Nadase Sarm1 antibodyAnti-Hsarm1 antibodyAnti-Nadp(+ Hydrolase Sarm1 antibodyAnti-Sterile Alpha And Armadillo Repeat Protein antibodyAnti-Sterile Alpha And Tir Motif-Containing Protein 1 antibodyAnti-Sterile Alpha Motif Domain-Containing Protein 2 antibodyAnti-Myd88-5 antibodyAnti-Sam Domain-Containing Protein 2 antibodyAnti-Tir-1 Homolog antibodyAnti-Hstir antibodyAnti-SARM1 antibodyAnti-KIAA0524 antibodyAnti-SAMD2 antibodyAnti-SARM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
