| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Gtp-Binding Protein Sar1b (1-198) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SAR1B |
| Gene ID: |
51128 |
| Uniprot ID: |
SAR1B_HUMAN |
| Immunogen Region: |
1-198 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human SAR1B (NP_057187.1). |
| Immunogen Sequence: |
MSFIFDWIYSGFSSVLQFLG LYKKTGKLVFLGLDNAGKTT LLHMLKDDRLGQHVPTLHPT SEELTIAGMTFTTFDLGGHV QARRVWKNYLPAINGIVFLV DCADHERLLESKEELDSLMT DETIANVPILILGNKIDRPE AISEERLREMFGLYGQTTGK GSISLKELNARPLEVFMCSV LKRQGYGEGFRWMAQYID |
| Tissue Specificity | Expressed in many tissues including small intestine, liver, muscle and brain. |
| Function | GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. |
| Protein Name | Gtp-Binding Protein Sar1bGtp-Binding Protein BGtbpb |
| Database Links | Reactome: R-HSA-1655829Reactome: R-HSA-204005Reactome: R-HSA-2132295Reactome: R-HSA-5694530Reactome: R-HSA-8963888Reactome: R-HSA-9705671Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinGolgi ApparatusGolgi Stack MembraneAssociated With The Endoplasmic Reticulum And Golgi StacksIn Particular In The Juxta-Nuclear Golgi Region |
| Alternative Antibody Names | Anti-Gtp-Binding Protein Sar1b antibodyAnti-Gtp-Binding Protein B antibodyAnti-Gtbpb antibodyAnti-SAR1B antibodyAnti-SARA2 antibodyAnti-SARB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and SRI knockout (KO) HeLa cells, using [KO Validated] SRI Rabbit polyclonal antibody (STJ11100797) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89733/358211/STJ11100797_1__02864.1713122535.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SRI knockout (KO) HeLa cells, using [KO Validated] SRI Rabbit polyclonal antibody (STJ11100797) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")