| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SAG |
| Gene ID: | 6295 |
| Uniprot ID: | ARRS_HUMAN |
| Immunogen Region: | 1-405 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-405 of human SAG (NP_000532.2). |
| Immunogen Sequence: | MAASGKTSKSEPNHVIFKKI SRDKSVTIYLGNRDYIDHVS QVQPVDGVVLVDPDLVKGKK VYVTLTCAFRYGQEDIDVIG LTFRRDLYFSRVQVYPPVGA ASTPTKLQESLLKKLGSNTY PFLLTFPDYLPCSVMLQPAP QDSGKSCGVDFEVKAFATDS TDAEEDKIPKKSSVRLLIRK VQHAPLEMGPQPRAEAAWQF FMSDKPLHLAVSLNKEIYFH GEPIPVTVTVTNNTEKTVK |
| Tissue Specificity | Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level). |
| Function | Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells. |
| Protein Name | S-Arrestin48 Kda ProteinRetinal S-AntigenS-AgRod Photoreceptor Arrestin |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859 |
| Cellular Localisation | Cell ProjectionCiliumPhotoreceptor Outer SegmentMembranePeripheral Membrane ProteinHighly Expressed In Photoreceptor Outer Segments In Light-Exposed RetinaEvenly Distributed Throughout Rod Photoreceptor Cells In Dark-Adapted RetinaPredominantly Dectected At The Proximal Region Of Photoreceptor Outer SegmentsNear Disk Membranes |
| Alternative Antibody Names | Anti-S-Arrestin antibodyAnti-48 Kda Protein antibodyAnti-Retinal S-Antigen antibodyAnti-S-Ag antibodyAnti-Rod Photoreceptor Arrestin antibodyAnti-SAG antibody |
Information sourced from Uniprot.org