Anti-S1PR5 antibody (307-398) (STJ11103195)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal S1PR5 (307-398) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | S1PR5 |
| Gene ID | 53637 |
| Uniprot ID | S1PR5_HUMAN |
| Immunogen Region | 307-398 |
| Immunogen Sequence | TLTNRDLRHALLRLVCCGRH SCGRDPSGSQQSASAAEASG GLRRCLPPGLDGSFSGSERS SPQRDGLDTSGSTGSPGAPT AARTLVSEPAAD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 307-398 of human S1PR5 (NP_110387.1). |
Additional Info
| Tissue Specificity | Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. |
| Function | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins. May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. |
| Protein Name | Sphingosine 1-Phosphate Receptor 5S1p Receptor 5S1p5Endothelial Differentiation G-Protein-Coupled Receptor 8Sphingosine 1-Phosphate Receptor Edg-8S1p Receptor Edg-8 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-419408 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sphingosine 1-Phosphate Receptor 5 antibodyAnti-S1p Receptor 5 antibodyAnti-S1p5 antibodyAnti-Endothelial Differentiation G-Protein-Coupled Receptor 8 antibodyAnti-Sphingosine 1-Phosphate Receptor Edg-8 antibodyAnti-S1p Receptor Edg-8 antibodyAnti-S1PR5 antibodyAnti-EDG8 antibody |
Information sourced from Uniprot.org