| Function | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Receptor for the chemokine-like protein FAM19A5. Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration. In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche. |
| Protein Name | Sphingosine 1-Phosphate Receptor 2S1p Receptor 2S1p2Endothelial Differentiation G-Protein Coupled Receptor 5Sphingosine 1-Phosphate Receptor Edg-5S1p Receptor Edg-5 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-419408 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sphingosine 1-Phosphate Receptor 2 antibodyAnti-S1p Receptor 2 antibodyAnti-S1p2 antibodyAnti-Endothelial Differentiation G-Protein Coupled Receptor 5 antibodyAnti-Sphingosine 1-Phosphate Receptor Edg-5 antibodyAnti-S1p Receptor Edg-5 antibodyAnti-S1PR2 antibodyAnti-EDG5 antibody |
Information sourced from Uniprot.org
