| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/IP/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:100-1:200 IF/ICC:1:50-1:200 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | S100P |
| Gene ID: | 6286 |
| Uniprot ID: | S100P_HUMAN |
| Immunogen Region: | 1-95 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-95 of human S100P (NP_005971.1). |
| Immunogen Sequence: | MTELETAMGMIIDVFSRYSG SEGSTQTLTKGELKVLMEKE LPGFLQSGKDKDAVDKLLKD LDANGDAQVDFSEFIVFVAA ITSACHKYFEKAGLK |
| Tissue Specificity | Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. |
| Function | May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). |
| Protein Name | Protein S100-P Migration-Inducing Gene 9 Protein Mig9 Protein S100-E S100 Calcium-Binding Protein P |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Nucleus Cytoplasm Cell Projection Microvillus Membrane Colocalizes With S100pbp In The Nucleus Colocolizes With Ezr In The Microvilli In A Calcium-Dependent Manner |
| Alternative Antibody Names | Anti-Protein S100-P antibody Anti-Migration-Inducing Gene 9 Protein antibody Anti-Mig9 antibody Anti-Protein S100-E antibody Anti-S100 Calcium-Binding Protein P antibody Anti-S100P antibody Anti-S100E antibody |
Information sourced from Uniprot.org