• Western blot analysis of 1) 293T, 2) Mouse Brain Tissue with S100 Rabbit pAb diluted at 1:2,000.
  • Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using S100Rabbit pAb diluted at 1:200.

Anti-S100A1 antibody (STJ197337)

SKU:
STJ197337

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Protein S100-A1 is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: S100A1
Gene ID: 6271
Uniprot ID: S10A1_HUMAN
Specificity: The antibody detects endogenous S100 protein
Immunogen: Recombinant Protein of S100
Post Translational Modifications Glutathionylated.glutathionylation increases affinity to calcium about 10-fold.
Function Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole.
Protein Name Protein S100-A1
S-100 Protein Alpha Chain
S-100 Protein Subunit Alpha
S100 Calcium-Binding Protein A1
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-166058
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5686938
Cellular Localisation Cytoplasm
Sarcoplasmic Reticulum
Mitochondrion
Alternative Antibody Names Anti-Protein S100-A1 antibody
Anti-S-100 Protein Alpha Chain antibody
Anti-S-100 Protein Subunit Alpha antibody
Anti-S100 Calcium-Binding Protein A1 antibody
Anti-S100A1 antibody
Anti-S100A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance