| Host: |
Mouse |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Protein S100-A1 (1-50 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
PT1428 |
| Conjugation: |
Unconjugated |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: |
IHC-P 1:100-500IF 1:100-500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
S100A1 |
| Gene ID: |
6271 |
| Uniprot ID: |
S10A1_HUMAN |
| Immunogen Region: |
1-50 aa |
| Specificity: |
This antibody detects endogenous levels of S100A1 at Human |
| Immunogen: |
Synthesized peptide derived from the human S100A1 at the amino acid range 1-50 |
| Post Translational Modifications | Glutathionylated.glutathionylation increases affinity to calcium about 10-fold. |
| Function | Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole. |
| Protein Name | Protein S100-A1S-100 Protein Alpha ChainS-100 Protein Subunit AlphaS100 Calcium-Binding Protein A1 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-166058Reactome: R-HSA-5602498Reactome: R-HSA-5603041Reactome: R-HSA-5686938 |
| Cellular Localisation | CytoplasmSarcoplasmic ReticulumMitochondrion |
| Alternative Antibody Names | Anti-Protein S100-A1 antibodyAnti-S-100 Protein Alpha Chain antibodyAnti-S-100 Protein Subunit Alpha antibodyAnti-S100 Calcium-Binding Protein A1 antibodyAnti-S100A1 antibodyAnti-S100A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
