| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-RYR3 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | RYR3 |
| Gene ID: | 6263 |
| Uniprot ID: | RYR3_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | Specific for RYR3. |
| Immunogen: | A synthetic peptide from c-terminal region of human Ryanodine receptor 3 (RYR3) conjugated to blue carrier protein was used as the antigen. |
| Function | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis. Plays a role in cellular calcium signaling. |
| Protein Name | Ryanodine Receptor 3Ryr-3Ryr3Brain Ryanodine Receptor-Calcium Release ChannelBrain-Type Ryanodine ReceptorType 3 Ryanodine Receptor |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Sarcoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ryanodine Receptor 3 antibodyAnti-Ryr-3 antibodyAnti-Ryr3 antibodyAnti-Brain Ryanodine Receptor-Calcium Release Channel antibodyAnti-Brain-Type Ryanodine Receptor antibodyAnti-Type 3 Ryanodine Receptor antibodyAnti-RYR3 antibodyAnti-HBRR antibody |
Information sourced from Uniprot.org