| Post Translational Modifications | Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels. Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium. |
| Function | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. |
| Protein Name | Ryanodine Receptor 2Ryr-2Ryr2Hryr-2Cardiac Muscle Ryanodine ReceptorCardiac Muscle Ryanodine Receptor-Calcium Release ChannelType 2 Ryanodine Receptor |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Sarcoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ryanodine Receptor 2 antibodyAnti-Ryr-2 antibodyAnti-Ryr2 antibodyAnti-Hryr-2 antibodyAnti-Cardiac Muscle Ryanodine Receptor antibodyAnti-Cardiac Muscle Ryanodine Receptor-Calcium Release Channel antibodyAnti-Type 2 Ryanodine Receptor antibodyAnti-RYR2 antibody |
Information sourced from Uniprot.org
