| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ryanodine Receptor 1 (800-900) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RYR1 |
| Gene ID: |
6261 |
| Uniprot ID: |
RYR1_HUMAN |
| Immunogen Region: |
800-900 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human RYR1 (NP_000531.2). |
| Immunogen Sequence: |
KFLPPPGYAPCHEAVLPRER LHLEPIKEYRREGPRGPHLV GPSRCLSHTDFVPCPVDTVQ IVLPPHLERIREKLAENIHE LWALTRIEQGWTYGPVRDDN K |
| Tissue Specificity | Skeletal muscle and brain (cerebellum and hippocampus). |
| Post Translational Modifications | Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2843. Activated by reversible S-nitrosylation. Repeated very high-level exercise increases S-nitrosylation. |
| Function | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis. |
| Protein Name | Ryanodine Receptor 1Ryr-1Ryr1Skeletal Muscle Calcium Release ChannelSkeletal Muscle Ryanodine ReceptorSkeletal Muscle-Type Ryanodine ReceptorType 1 Ryanodine Receptor |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Sarcoplasmic Reticulum MembraneMulti-Pass Membrane ProteinThe Number Of Predicted Transmembrane Domains Varies Between OrthologsBoth N-Terminus And C-Terminus Are Cytoplasmic |
| Alternative Antibody Names | Anti-Ryanodine Receptor 1 antibodyAnti-Ryr-1 antibodyAnti-Ryr1 antibodyAnti-Skeletal Muscle Calcium Release Channel antibodyAnti-Skeletal Muscle Ryanodine Receptor antibodyAnti-Skeletal Muscle-Type Ryanodine Receptor antibodyAnti-Type 1 Ryanodine Receptor antibodyAnti-RYR1 antibodyAnti-RYDR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
