| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RING1 and YY1-binding protein is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RYBP |
| Gene ID: |
23429 |
| Uniprot ID: |
RYBP_HUMAN |
| Specificity: |
This antibody detects endogenous levels of RYBP at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human RYBP |
| Post Translational Modifications | Monoubiquitinated. |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3. |
| Protein Name | Ring1 And Yy1-Binding ProteinApoptin-Associating Protein 1Apap-1Death Effector Domain-Associated FactorDed-Associated FactorYy1 And E4tf1-Associated Factor 1 |
| Database Links | Reactome: R-HSA-8939243Reactome: R-HSA-8953750 |
| Cellular Localisation | NucleusCytoplasmNucleoplasmPrimarily Found In The NucleusDetected In A Punctate Pattern Likely To Represent Polycomb Group (Pcg) Bodies |
| Alternative Antibody Names | Anti-Ring1 And Yy1-Binding Protein antibodyAnti-Apoptin-Associating Protein 1 antibodyAnti-Apap-1 antibodyAnti-Death Effector Domain-Associated Factor antibodyAnti-Ded-Associated Factor antibodyAnti-Yy1 And E4tf1-Associated Factor 1 antibodyAnti-RYBP antibodyAnti-DEDAF antibodyAnti-YEAF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
