Anti-RTN4RL2 antibody (290-370 aa) (STJ192372)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 290-370
General Information
| Short Description | Rabbit polyclonal anti-Reticulon-4 receptor-like 2 (290-370 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RTN4RL2 |
| Gene ID | 349667 |
| Uniprot ID | R4RL2_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 290-370 |
| Immunogen Region | 290-370 aa |
| Specificity | R4RL2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells.is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein. N-glycosylated. |
| Function | Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG. Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis.protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. |
| Protein Name | Reticulon-4 Receptor-Like 2Nogo Receptor-Like 3Nogo-66 Receptor Homolog 1Nogo-66 Receptor-Related Protein 2Ngr2 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftCell ProjectionDendritePerikaryonAxonLocalized To The Surface Of NeuronsIncluding AxonsDetected Close To SynapsesBut Is Excluded From Synapses |
| Alternative Antibody Names | Anti-Reticulon-4 Receptor-Like 2 antibodyAnti-Nogo Receptor-Like 3 antibodyAnti-Nogo-66 Receptor Homolog 1 antibodyAnti-Nogo-66 Receptor-Related Protein 2 antibodyAnti-Ngr2 antibodyAnti-RTN4RL2 antibodyAnti-NGRH1 antibodyAnti-NGRL3 antibody |
Information sourced from Uniprot.org