| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Reticulon-4 receptor-like 2 (290-370 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RTN4RL2 |
| Gene ID: |
349667 |
| Uniprot ID: |
R4RL2_HUMAN |
| Immunogen Region: |
290-370 aa |
| Specificity: |
R4RL2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 290-370 |
| Post Translational Modifications | Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells.is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein. N-glycosylated. |
| Function | Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG. Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis.protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. |
| Protein Name | Reticulon-4 Receptor-Like 2Nogo Receptor-Like 3Nogo-66 Receptor Homolog 1Nogo-66 Receptor-Related Protein 2Ngr2 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftCell ProjectionDendritePerikaryonAxonLocalized To The Surface Of NeuronsIncluding AxonsDetected Close To SynapsesBut Is Excluded From Synapses |
| Alternative Antibody Names | Anti-Reticulon-4 Receptor-Like 2 antibodyAnti-Nogo Receptor-Like 3 antibodyAnti-Nogo-66 Receptor Homolog 1 antibodyAnti-Nogo-66 Receptor-Related Protein 2 antibodyAnti-Ngr2 antibodyAnti-RTN4RL2 antibodyAnti-NGRH1 antibodyAnti-NGRL3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
