• Western blot analysis using R-Spondin monoclonal antibody against recombinant R-spondin1 protein (1) and R-spondin1 (aa21-263) -hIgGFc transfected HEK293 cell lysate (2).

Anti-RSPO1 antibody [7A6] (STJ98368)

SKU:
STJ98368

£139.00 - £336.00
Current Stock:
Host: Mouse
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-R-spondin-1 is suitable for use in Western Blot and ELISA research applications.
Clonality: Monoclonal
Clone ID: 7A6
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RSPO1
Gene ID: 284654
Uniprot ID: RSPO1_HUMAN
Specificity: R-Spondin Monoclonal Antibody detects endogenous levels of R-Spondin protein.
Immunogen: Purified recombinant fragment of R-spondin1 expressed in E. Coli.
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1.
Protein Name R-Spondin-1
Roof Plate-Specific Spondin-1
Hrspo1
Database Links Reactome: R-HSA-4641263
Cellular Localisation Secreted
Nucleus
Seems To Mainly Localize To Nucleoli
Alternative Antibody Names Anti-R-Spondin-1 antibody
Anti-Roof Plate-Specific Spondin-1 antibody
Anti-Hrspo1 antibody
Anti-RSPO1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance