| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RSAD2 |
| Gene ID: |
91543 |
| Uniprot ID: |
RSAD2_HUMAN |
| Immunogen Region: |
118-361 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 118-361 of human RSAD2 (NP_542388.2). |
| Immunogen Sequence: |
EKINFSGGEPFLQDRGEYLG KLVRFCKVELRLPSVSIVSN GSLIRERWFQNYGEYLDILA ISCDSFDEEVNVLIGRGQGK KNHVENLQKLRRWCRDYRVA FKINSVINRFNVEEDMTEQI KALNPVRWKVFQCLLIEGEN CGEDALREAERFVIGDEEFE RFLERHKEVSCLVPESNQKM KDSYLILDEYMRFLNCRKGR KDPSKSILDVGVEEAIKFSG FDEKMFLKRGGKYIWSKAD |
| Post Translational Modifications | Acetylated by HAT1. HAT1-mediated acetylation of Lys-197 in turn recruits UBE4A that stimulates RSAD2 polyubiquitination leading to proteasomal degradation. 'Lys-6'-linked polyubiquitination at Lys-206 leads to RSAD2 protein degradation. |
| Function | Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), zika virus, and human immunodeficiency virus (HIV-1). Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. |
| Protein Name | S-Adenosylmethionine-Dependent Nucleotide Dehydratase Rsad2SandCytomegalovirus-Induced Gene 5 ProteinRadical S-Adenosyl Methionine Domain-Containing Protein 2Virus Inhibitory Protein - Endoplasmic Reticulum-Associated - Interferon-InducibleViperin |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideGolgi ApparatusEndoplasmic ReticulumLipid DropletMitochondrionMitochondrion Inner MembraneMitochondrion Outer MembraneInfection With Human Cytomegalovirus (Hcmv) Causes Relocation To The Golgi Apparatus And To Cytoplasmic Vacuoles Which Also Contain Hcmv Proteins Glycoprotein B And Pp28Interaction With Human Cytomegalovirus/Hhv-5 Protein Vmia/Ul37 Results In Its Relocalization From The Endoplasmic Reticulum To The Mitochondria |
| Alternative Antibody Names | Anti-S-Adenosylmethionine-Dependent Nucleotide Dehydratase Rsad2 antibodyAnti-Sand antibodyAnti-Cytomegalovirus-Induced Gene 5 Protein antibodyAnti-Radical S-Adenosyl Methionine Domain-Containing Protein 2 antibodyAnti-Virus Inhibitory Protein - Endoplasmic Reticulum-Associated - Interferon-Inducible antibodyAnti-Viperin antibodyAnti-RSAD2 antibodyAnti-CIG5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
