Anti-RRM2 antibody (10-117) [S6MR] (STJ11101866)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal RRM2 (10-117) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S6MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RRM2 |
| Gene ID | 6241 |
| Uniprot ID | RIR2_HUMAN |
| Immunogen Region | 10-117 |
| Immunogen Sequence | PITDPQQLQLSPLKGLSLVD KENTPPALSGTRVLASKTAR RIFQEPTEPKTKAAAPGVED EPLLRENPRRFVIFPIEYHD IWQMYKKAEASFWTAEEVDL SKDIQHWE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 10-117 of human RRM2 (P31350). |
Additional Info
| Post Translational Modifications | Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. Phosphorylated on Thr-33 by CDK1 and CDK2.predominantly in G2 and M phase. Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex.leading to its degradation by the proteasome. |
| Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. |
| Protein Name | Ribonucleoside-Diphosphate Reductase Subunit M2Ribonucleotide Reductase Small ChainRibonucleotide Reductase Small Subunit |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-69205Reactome: R-HSA-8953750 |
| Cellular Localisation | CytoplasmNucleusLocalized To The Cytoplasm In S Phase CellsMay Localize To The Nucleus In G2 Phase Cells |
| Alternative Antibody Names | Anti-Ribonucleoside-Diphosphate Reductase Subunit M2 antibodyAnti-Ribonucleotide Reductase Small Chain antibodyAnti-Ribonucleotide Reductase Small Subunit antibodyAnti-RRM2 antibodyAnti-RR2 antibody |
Information sourced from Uniprot.org