| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S3MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPS6KB2 |
| Gene ID: | 6199 |
| Uniprot ID: | KS6B2_HUMAN |
| Immunogen Region: | 1-120 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human p70 S6 Kinase 2 (Q9UBS0). |
| Immunogen Sequence: | MAAVFDLDLETEEGSEGEGE PELSPADACPLAELRAAGLE PVGHYEEVELTETSVNVGPE RIGPHCFELLRVLGKGGYGK VFQVRKVQGTNLGKIYAMKV LRKAKIVRNAKDTAHTRAER |
| Post Translational Modifications | Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention. |
| Function | Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7. |
| Protein Name | Ribosomal Protein S6 Kinase Beta-2 S6k-Beta-2 S6k2 70 Kda Ribosomal Protein S6 Kinase 2 P70s6k2 P70-S6k 2 S6 Kinase-Related Kinase Srk Serine/Threonine-Protein Kinase 14b P70 Ribosomal S6 Kinase Beta S6k-Beta P70 S6 Kinase Beta P70 S6k-Beta P70 S6kb P70-Beta |
| Database Links | Reactome: R-HSA-198693 Reactome: R-HSA-5674400 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Ribosomal Protein S6 Kinase Beta-2 antibody Anti-S6k-Beta-2 antibody Anti-S6k2 antibody Anti-70 Kda Ribosomal Protein S6 Kinase 2 antibody Anti-P70s6k2 antibody Anti-P70-S6k 2 antibody Anti-S6 Kinase-Related Kinase antibody Anti-Srk antibody Anti-Serine/Threonine-Protein Kinase 14b antibody Anti-P70 Ribosomal S6 Kinase Beta antibody Anti-S6k-Beta antibody Anti-P70 S6 Kinase Beta antibody Anti-P70 S6k-Beta antibody Anti-P70 S6kb antibody Anti-P70-Beta antibody Anti-RPS6KB2 antibody Anti-STK14B antibody |
Information sourced from Uniprot.org