Anti-RPS6KB2 antibody (1-120) [S3MR] (STJ11102423)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal P70 S6 Kinase beta (1-120) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S3MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RPS6KB2 |
| Gene ID | 6199 |
| Uniprot ID | KS6B2_HUMAN |
| Immunogen Region | 1-120 |
| Immunogen Sequence | MAAVFDLDLETEEGSEGEGE PELSPADACPLAELRAAGLE PVGHYEEVELTETSVNVGPE RIGPHCFELLRVLGKGGYGK VFQVRKVQGTNLGKIYAMKV LRKAKIVRNAKDTAHTRAER |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human p70 S6 Kinase 2 (Q9UBS0). |
Additional Info
| Post Translational Modifications | Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention. |
| Function | Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7. |
| Protein Name | Ribosomal Protein S6 Kinase Beta-2S6k-Beta-2S6k270 Kda Ribosomal Protein S6 Kinase 2P70s6k2P70-S6k 2S6 Kinase-Related KinaseSrkSerine/Threonine-Protein Kinase 14bP70 Ribosomal S6 Kinase BetaS6k-BetaP70 S6 Kinase BetaP70 S6k-BetaP70 S6kbP70-Beta |
| Database Links | Reactome: R-HSA-198693Reactome: R-HSA-5674400 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ribosomal Protein S6 Kinase Beta-2 antibodyAnti-S6k-Beta-2 antibodyAnti-S6k2 antibodyAnti-70 Kda Ribosomal Protein S6 Kinase 2 antibodyAnti-P70s6k2 antibodyAnti-P70-S6k 2 antibodyAnti-S6 Kinase-Related Kinase antibodyAnti-Srk antibodyAnti-Serine/Threonine-Protein Kinase 14b antibodyAnti-P70 Ribosomal S6 Kinase Beta antibodyAnti-S6k-Beta antibodyAnti-P70 S6 Kinase Beta antibodyAnti-P70 S6k-Beta antibodyAnti-P70 S6kb antibodyAnti-P70-Beta antibodyAnti-RPS6KB2 antibodyAnti-STK14B antibody |
Information sourced from Uniprot.org