| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Active regulator of SIRT1 (71-120 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPS19BP1 |
| Gene ID: | 91582 |
| Uniprot ID: | AROS_HUMAN |
| Immunogen Region: | 71-120 aa |
| Specificity: | Ribosomal Protein S19BP Polyclonal Antibody detects endogenous levels of Ribosomal Protein S19BP protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human RPS19BP1 at the amino acid range 71-120 |
| Post Translational Modifications | Citrullinated by PADI4. |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1. Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. |
| Protein Name | Active Regulator Of Sirt1 40s Ribosomal Protein S19-Binding Protein 1 Rps19-Binding Protein 1 S19bp |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | Nucleus Nucleolus |
| Alternative Antibody Names | Anti-Active Regulator Of Sirt1 antibody Anti-40s Ribosomal Protein S19-Binding Protein 1 antibody Anti-Rps19-Binding Protein 1 antibody Anti-S19bp antibody Anti-RPS19BP1 antibody Anti-AROS antibody |
Information sourced from Uniprot.org