| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-RPL3 (1-260) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPL3 |
| Gene ID: | 6122 |
| Uniprot ID: | RL3_HUMAN |
| Immunogen Region: | 1-260 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RPL3 (NP_000958.1). |
| Immunogen Sequence: | MSHRKFSAPRHGSLGFLPRK RSSRHRGKVKSFPKDDPSKP VHLTAFLGYKAGMTHIVREV DRPGSKVNKKEVVEAVTIVE TPPMVVVGIVGYVETPRGLR TFKTVFAEHISDECKRRFYK NWHKSKKKAFTKYCKKWQDE DGKKQLEKDFSSMKKYCQVI RVIAHTQMRLLPLRQKKAHL MEIQVNGGTVAEKLDWARER LEQQVPVNQVFGQDEMIDVI GVTKGKGYKGVTSRWHTKK |
| Post Translational Modifications | Constitutively monomethylated at His-245 by METTL18. Methylation at His-245 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins. It is not required for incorporation of RPL3 into ribosomes. |
| Function | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. |
| Protein Name | Large Ribosomal Subunit Protein Ul360s Ribosomal Protein L3Hiv-1 Tar Rna-Binding Protein BTarbp-B |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-156902Reactome: R-HSA-1799339Reactome: R-HSA-192823Reactome: R-HSA-2408557Reactome: R-HSA-6791226Reactome: R-HSA-72689Reactome: R-HSA-72706Reactome: R-HSA-72764Reactome: R-HSA-9010553Reactome: R-HSA-9633012Reactome: R-HSA-975956Reactome: R-HSA-975957 |
| Cellular Localisation | NucleusNucleolusCytoplasm |
| Alternative Antibody Names | Anti-Large Ribosomal Subunit Protein Ul3 antibodyAnti-60s Ribosomal Protein L3 antibodyAnti-Hiv-1 Tar Rna-Binding Protein B antibodyAnti-Tarbp-B antibodyAnti-RPL3 antibodyAnti-OK antibodyAnti-SW-cl.32 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
